Dr. Brett and Dr. Jess discuss supplement quality, gene activation, NRF2, the Tri-Synergizer, liquid collagen and P84 on Wellness Wednesday.

Are Your Supplements Actually Worth It? A Practical Conversation About Smarter Health Choices

September 17, 20264 min read
Custom HTML/CSS/JavaScript


Walk into any health store and you will find hundreds of vitamins, powders, herbs and supplements all promising better health. But how do you actually know what you need, whether what you are taking is working, and whether the company you are trusting is even worth trusting?

In this Wellness Wednesday conversation, Dr. Brett sits down with Dr. Jess, a Doctor of Chiropractic with 18 years of clinical experience and a member of the LifeVantage Scientific Advisory Board, for one of the most practical and eye-opening conversations we have ever had on this platform. Dr. Jess brings her perspective as both a clinician who has used supplementation throughout her entire 18-year practice and as a farmer's wife who understands firsthand why soil depletion is making even the cleanest diets fall short. Together they break down everything most people never ask about the supplements they are taking every single day.

The conversation covers the difference between supplementing deficiencies and actually activating the body's own cellular response systems — and why that distinction changes everything about how you think about your health.

In This Episode We Discuss:

  • Why even people eating clean whole food diets are still deficient today, and how soil depletion is a real and growing problem that affects nutritional quality at the source

  • What to look for when evaluating a supplement company, including batch testing standards, ownership and profit structure, third-party testing, board composition, research quality, bioavailability and ingredient integrity

  • Why not all supplements are created equal and how the same product at different price points or brands can perform completely differently inside the body

  • The difference between supplementing deficiencies and activation — what an activator actually is, how it turns on the body's innate ability to produce what it once produced, and why this is fundamentally different from anything else in the supplement space

  • How the NRF2 pathway controls the body's antioxidant production, why glutathione is far more powerful than any external antioxidant you could take, and how activating this switch at the cellular level changes what the body can do

  • The Tri-Synergizer and how NRF2, NRF1 and NAD work together as the body's sanitation department, energy production system and cellular communication network

  • Why Dr. Jess personally leads with the Tri-Synergizer, liquid collagen and Axio — and why she calls the Healthy Glow Stack her chiropractor's best friend

  • How the Healthy Glow Stack cuts the body's stress load by a third and doubles collagen density in 8 weeks when taken together

  • What P84 is, why it took Dr. Jess until day three to crave it, and why it is the first gut product she has ever found that is truly all-inclusive in one formula

  • Why people who add activation as their foundation often find they need fewer supplements overall — and why that is a sign it is working

  • How to know if what you are taking is actually doing something: lab work, wearable tracking, muscle testing, how your skin and hair are changing and the basics like recovery, sleep, weight regulation and bowel health

Key Takeaways

  • You cannot eat your way out of supplement deficiencies in today's food system, and you cannot supplement your way out of a poor diet. Activation gives the body the foundation to get more out of everything else

  • The most expensive supplement is the one that does not work. Quality, sourcing, batch testing and bioavailability matter far more than price

  • A supplement addresses a deficiency. An activator turns on the body's own cellular systems to produce what it was designed to produce. These are fundamentally different categories

  • Of 10,000 people who take the NRF2 activator, 9,999 get the anticipated result. No pharmaceutical and no other supplement has a clinical result like that

  • If you are not sure where to start, start with activation. The science is solid, the confidence is there and everything else builds better on that foundation

  • How well you regulate — your temperature, your emotions, your stress response, your sleep, your recovery — is one of the best indicators of how well your cellular systems are functioning

Whether you are brand new to supplements, have a cabinet full of them and are not sure if any of them are working, or simply want to understand what makes cellular activation different from everything else out there, this conversation will change the way you approach your health from the inside out.

Thank you for joining us for another Wellness Wednesday discussion.


Save these links in your records so you can easily return to them.

You can listen to all recordings via audio by visiting this link:

https://biohackandactivate.com/activationpodcast

You can also find us on Apple Podcasts here:

https://podcasts.apple.com/us/podcast/wellness-wednesday-activation-podcast/id1860715006

And on Spotify here:

https://open.spotify.com/show/6wDumT9yTsCzNWD9LxzeIm

We release new episodes every week, so there is always fresh content to guide you on your wellness journey. Tune in, get inspired, and start supporting your body and mind from the inside out.

Thank you for joining us for another Wellness Wednesday discussion.

The Fab Collab

The Fab Collab

The Wellness Wednesday Activation Podcast is a weekly conversation about real health that begins in your gut, your cells, and the choices you make every day. Each episode features experts who bring proactive perspectives on topics such as hormones, metabolism, energy, stress, sleep, detoxification, and more. These discussions go beyond surface-level advice, uncovering the science of how your body truly works and offering practical strategies you can apply immediately. At its core, the podcast is about empowerment, helping you reclaim ownership of your health by understanding the foundational truth that when you repair and support the gut and the cells, everything else in your body functions better.

Back to Blog